Connections Wellness Denton

3312 Teasley Ln, Bldg 100, Ste 105
Denton, TX 76210

Connections Wellness Frisco

255 Lebanon Rd, Ste 124
Friso, TX 75036

RestoreBrain Irving

580 Decker Drive, Ste 260,
Irving, TX 75062

Maxhealth Colleyville

5207 Heritage Ave
Colleyville, TX 76034

Monday - Friday

8:00AM to 5:00PM

(888)990-0663

ESKETAMINE THERAPY

SPRAVATO® is the first nasal spray medication specifically for adults with treatment-resistant depression (TRD).

Esketamine Therapy

spravato treatment

At Restore Brain, we offer a form of ketamine therapy known as esketamine therapy. Our esketamine patients self-administer SPRAVATO™, an FDA-approved type of esketamine, in our office during their treatment appointments. This medicine serves as a new option for patients who have treatment-resistant depression.

What Is Esketamine?

Esketamine is a version of the ketamine molecule used to address treatment-resistant depression. It stimulates the production of glutamate, a neurotransmitter that creates new neural connections and influences many brain functions. Compared to ketamine, esketamine targets more brain connections and needs a lower dose to relieve depression symptoms. Scientists developed esketamine after finding that the anesthetic ketamine triggered glutamate production.

ketamine therapy

Is Esketamine FDA-Approved?

SPRAVATO™, a branded version of esketamine, has FDA approval for TRD (Treatment Resistant Depression). It comes in the form of a nasal spray that the patient takes under a doctor’s direct supervision.

Johnson & Johnson submitted five Phase 3 studies on the drug: three-short term studies, one maintenance study, and a long-term safety study. Two of those turned up positive results. One was a randomized trial in adults under age 65 with treatment-resistant depression who were started on an oral antidepressant and intranasal esketamine. After a month, roughly 70% of patients who received the treatment responded compared to just over half in a placebo group. The researchers considered an improvement of 50% or more on a common depression rating scale as a successful response.

As a result of findings like these, the FDA approved SPRAVATO™ for supervised use in March 2019. Because of esketamine’s potential side effects, the FDA requires doctors to distribute SPRAVATO™ under the Risk Evaluation and Mitigation Strategy (REMS).

The SPRAVATO™ REMS (Risk Evaluation and Mitigation Strategy)

To protect patients, SPRAVATO™ treatment has the following measures in place:

  • Patients may only receive and take SPRAVATO™ in a medically supervised setting
  • Pharmacies and health care organizations that distribute SPRAVATO™ must have special certification
  • Each patient receives detailed information on the potential severe side effects of SPRAVATO™
  • Every SPRAVATO™ patient must enroll in a registry

What Are the Side Effects of Esketamine Nasal Spray?

During a SPRAVATO™ treatment session, the doctor monitors the patient for side effects after administration. These symptoms vary in severity, depending on the patient. The potential side effects of an esketamine treatment like SPRAVATO™ include:

  • Dizziness
  • Sedation
  • Disassociation
  • Anxiety
  • Decreased sensitivity or feeling
  • Lethargy
  • Nausea and vomiting
  • Feelings of impairment

What Are the Treatment Protocol and Dosage Recommendation for Esketamine?

A SPRAVATO™ treatment plan involves ongoing appointments where the patient self-administers the medicine. SPRAVATO™ comes in the form of a 28-milligram nasal spray device. Depending on how the patient reacts to the medication, they may take 56-milligram doses (two devices) or 84-milligram doses (three devices). For the first four weeks of treatment, the patient will visit twice a week for the induction phase, then once a week for the fifth to eighth weeks. After those first two phases, the doctor will recommend treatment once or twice a week.

TMS Therapy in the Dallas - Fort Worth Areas

We are proud to represent the areas of Arlington, North Richland Hills, Grapevine, Colleyville, Frisco, Euless, Bedford, Southlake, Keller, Irving, Las Colinas, Coppell, Flower Mound, Trophy Club, Hurst, Lewisville, Highland Village, Denton, Lake Dallas, Argyle, Corinth, Double Oak, Copper Canyon

Restore Brain accepts all major insurance providers including:

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